產(chǎn)品名稱：anti-human CD181 (CXCR1, IL-8RA) FITC eBio8F1-1-4 (8F1-1-4) 25 tests 產(chǎn)品貨號：eBioscience 11-1819-71 產(chǎn)品規(guī)格：25 tests Anti-Human CD181 (CXCR1) FITC Also known as: Interleukin-8 Receptor A, IL-8Ra, IL8RA Clone: eBio8F1-1-4 (8F1-1-4) RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 11-1819 Cat. No. Size 11-1819-71 25 tests 11-1819-42 100 tests Description: The eBio8F1-1-4 monoclonal antibody reacts with human CD181 (CXCR1, IL-8Rα). CD181 is a 67-70 kDa member of the 7-transmembrane spanning G-protein coupled receptor (GPCR) family. CD181 is expressed as a homodimer, or a heterodimer with CD182 (CXCR2, IL-8Rβ) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
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