產(chǎn)品名稱：anti-human CD115 (CSF-1R) Purified 12-3A3-1B10 100 ug 產(chǎn)品貨號：eBioscience 14-1159-82 產(chǎn)品規(guī)格：100 ug Anti-Human CD115 (c-fms) Purified Also known as: CSF1R, colony-stimulating factor 1 Receptor Clone: 12-3A3-1B10 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-1159 Cat. No. Size 14-1159-80 25 ug 14-1159-82 100 ug Description: CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.
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