產品名稱：Anti-Human Skp-2 (clone SJBCH) Purified, 100 ug
產品貨號：eBioscience 14-5697-82
產品規格：500 ug
Anti-Human S-Phase Kinase-associated protein 2 (Skp-2) Purified
Clone: SJBCH
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-5697
Cat. No. Size
14-5697-80  25 ug 
14-5697-82  100 ug 
Description: The monoclonal antibody SJBCH recognizes human Skp-2 (S-phase kinase-associated protein 2), a 47 kDa F-box protein that interacts with the Cyclin E-Cdk2 complex. Members of the F-box protein family are characterized by a 40 amino acid F-box motif, named after cyclin F. F-box proteins act as adapter proteins, associating with substate proteins and bringing them to the core of the ubiquitin ligase complex where they bind to Skp-2. Skp-2 associates with p27 and is required for the ubiquitination and subsequent degradation of p27 (cyclin-dependent kinase (Cdk) inhibitor). P27 binds to and inhibits cyclin E-cdk2 complexes, as a result preventing progression through the cell cycle. It is the Skp-2-dependent degradation of phorphorylated p27 that allows for the G1-S transition in both transformed cells and diploid fibroblasts.
Skp-2 has been reported to be overexpressed in a variety of cancer types and correlates with poor prognosis. Skp-2 overexpression has been documented in colon mucinous carcinoma, gastric adenocarcinoma, thymoma, melanoma, prostate adenocarcinoma, lung adenocarcinoma, and ER (estrogen receptor) negative breast cancers.

產品留言

標題

聯系人

聯系電話

內容

驗證碼

點擊換一張

注：1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!