產(chǎn)品名稱：anti-human/mouse/rat BLyS (CD257, BAFF) Purified Polyclonal 50 ug 產(chǎn)品貨號(hào)：eBioscience 14-6139-81 產(chǎn)品規(guī)格：50 ug Anti-CD257 (BAFF, BLyS) Purified Also known as: TNFSF13B, BLYS, TALL-1, TALL1, THANK, B-cell activating factor Clone: Polyclonal RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-6139 Cat. No. Size 14-6139-63 10 ug 14-6139-81 50 ug Description: The BLyS (BAFF) polyclonal antibody was raised against a peptide corresponding to amino acids 254 to 269 of human BAFF. Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Three receptors for BAFF were identified and designated TACI, BCMA and BAFF-R. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses. BAFF is involved in the development of autoimmune diseases including systemic lupus erythaematosus and rheumatoid arthritis.
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