產(chǎn)品名稱：Recombinant human TGFbeta3, 25 ug 產(chǎn)品貨號：eBioscience 14-8369-80 產(chǎn)品規(guī)格：25 ug Human TGF beta 3 Recombinant Protein Also known as: Transforming Growth Factor beta 3, TGF-beta3, TGFbeta3 RUO: For Research Use Only. Not for use in diagnostic procedures. SKU# 14-8369 Cat. No. Size 14-8369-62 5 ug 14-8369-80 25 ug Description: Transforming growth factor β3 (TGF-β3) is the third member of the transforming growth factor family of cytokines, which also includes TGF-β1 and -β2. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF bet ;3 is highly conserved across species, with mouse and human TGF beta 3 demonstrating 100% sequence homology and cross-species activity. The members of this family can be expressed by most cell types and exert pleiotropic effects, which include the suppression of B- and T-cell effector activity, mediation of tissue healing, and suppression of tumor proliferation. The promotion of CD4+CD25+ T-cell expansion is a newly discovered function of the TGF-β cytokines, and indicates an important role in the protection against autoimmunity.
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