產品名稱：Recombinant Human BAFF, 25 ug
產品貨號：eBioscience 14-8943-80
產品規格：25 ug
Human CD257 (BAFF, BLyS) Recombinant Protein
Also known as: TNFSF13B, BLYS, TALL-1, TALL1, THANK, B-cell activating factor
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-8943
Cat. No. Size
14-8943-62  5 ug 
14-8943-80  25 ug 
Description: Recombinant human BAFF (B-cell activating factor), also referred to as BlyS, is a type II transmembrane protein of the TNF superfamily. BAFF is found on T cells, macrophages and dendritic cells. BAFF contains a cytoplasmic domain, transmembrane domain and extracellular domain which can be cleaved between amino acid 133 and 134 to produce a soluble form detectable in serum. Receptors for BAFF include TACI, BAMBI and BAFFR. BAFF/BLyS is a B lymphocyte stimulatory molecule; it induces B cell proliferation and immunoglobulin secretion. In addition BAFF can provide a co-stimulation signal to T lymphocytes. Elevated levels of BAFF has been implicated in the pathogenesis of some autoimmune diseases (particularly) B cell diseases such as systemic lupus erythaematosus. Human and mouse BAFF share 86% amino acid sequence identity.

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