產品名稱：Recombinant Mouse M-CSF 25 ug
產品貨號：eBioscience 14-8983-80
產品規格：25 ug
Mouse M-CSF Recombinant Protein
Also known as: Macrophage colony stimulating factor, monocyte colony stimulating factor, CSF-1, MCSF
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-8983
Cat. No. Size
14-8983-62  5 ug 
14-8983-80  25 ug 
Description: Macrophage colony-stimulating factor (M-CSF or CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization.
M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. The secreted protein is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex.

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