產品名稱：anti-human PD-1 (CD279) Purified J116 100 ug
產品貨號：eBioscience 14-9989-82
產品規格：100 ug
Anti-Human CD279 (PD-1) Purified
Also known as: PD1
Clone: J116
RUO: For Research Use Only. Not for use in diagnostic procedures.
SKU# 14-9989
Cat. No. Size
14-9989-80  25 ug 
14-9989-82  100 ug 
Description: The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55 kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.

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