產(chǎn)品名稱：Irinotecan HCl trihydrate 產(chǎn)品貨號：LKT I6933 產(chǎn)品規(guī)格：10mg Description Irinotecan is inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication Topoisomerase I mediates the relaxation of super coiled DNA, and it's inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is therefore an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer. Specifications Cas No. 136572-09-3 Product ID I6933 Product Name Irinotecan HCl trihydrate Chemical Name [1,4'-Bipiperidine]-1'-carboxylic acid (4S)-4,11- diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo- 1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate Synonym Irinotecan hydrochloride trihydrate; Camptosar; Campto Formula Wt. 677.19 Melting Point 256.5oC Purity ≥98% Solubility Slightly soluble in water, ethanol, chloroform. Store Temp Ambient References Kellner U, Rudolph P, Parwaresch R. Onkologie. 23:424-430 (2000). Kalemkerian GP, Worden FP. Expert Opin Investing Drugs. 9:565-79 (2000). Saltz LB. Curr Oncol Rep. 1:155-160 (1999).
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