產品名稱：CA 125 IRMA
產    地：Demeditec 
產品貨號：DE4438
產品規格：96 Tests
產品說明：
Special remarks:
CLINICAL BACKGROUND
Biological activities
CA 125 is a high molecular weight mucin type glycoprotein, originally defined by the Oc 125 monoclonal antibody (Mab) established by Bast et al. Different epitopes, co-expressed with the Oc 125 epitope on the CA 125 antigen, have been used for the development of heterologous assays for determination of the CA 125 antigen.
Clinical applications
Approximately 90% of ovarian cancers are celomic epithelial carcinomas and contain a celomic epithelium-related glycoprotein designated CA 125. CA 125 can be localized in most serous, endometrioid, and clear cell ovarian carcinomas; mucinous tumors express this antigen less frequently. CA 125 is also found in the epithelium of the fallopian tubes, endometrium, and uterine cervix. Elevated CA 125 levels can result from abdominal diseases other than ovarian cancer. Although CA 125 is most consistently elevated in patients with epithelial ovarian cancer, it can be expressed in a number of gynaecologic (eg, endometrium, fallopian tube) and non-gynaecologic (eg, pancreas, breast, colon, lung) cancers. CA 125 levels are frequently elevated with tumor spread beyond the uterus.
PRINCIPLES  OF  THE METHOD
The CA 125-IRMA is a two-step immunoradiometric assay based on coated?tube separation.  Mab1, the capture antibody, is attached to the lower and inner surface of the plastic tube. Add calibrators or samples to the tubes. After incubation, washing removes the occasional excess of antigen. Addition of Mab2, the signal antibody labelled with 125I, will complete the system and trigger the immunological reaction.  After washing, the remaining radioactivity bound to the tube reflects the antigen concentration.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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