產品名稱：ß2-Microglobulin ELISA
產    地：Demeditec 
產品貨號：DE7610
產品規格：96 Tests
產品說明：
Special remarks:
Beta-2-Microglobulin is an indirect solid phase enzyme immunoassay (ELISA) for the quantitative measurement of b2-microglobulin in human urine, serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the diagnosis of lymphatic diseases and kidney dysfunctions.
Proteins passing the glomerular basal membrane of the kidney undergo differentiated filtering. The permeability is inversly proportional to the molecular weight (Albumin about 0.6 %, Myoglobulin about 75 %). Nevertheless, only minimal quantities of protein are detectable in urine, because big quantities of protein are reabsorbed by the tubuli. Elevated glomerular protein permeability and high tubular plasma protein elimination can be differentiated by measuring the molecular weight distribution of the eliminated proteins.
The pattern of eliminated proteins in urine give information about:
- elevated protein elimination          
- differentiation of proteinuria
- prediagnosis of a kidney defect    
- glomerular or tubular proteinuria
Diagnostically relevant proteins:      
- IgG (mw 150 kD)                         
- albumin (mw 66 kD)          
- a1-Microglobulin (mw 33 kD)       
- b2-microglobulin (mw 12 kD)
- retinol binding protein (mw 21 kD)
- immunoglobulin light chains (Bence-Jones protein) (22 kD)
b2-microglobulin has a molecular weight of 12 kD and belongs to the light chain part of membrane bound HLA antigens. It consists of two polypeptide chains, a heavy chain with antigenic structures and a light chain.
The determination of b2-microglobulin in serum or plasma is an aid in the clinical assessment of activation of the cellular immune system and a tumor marker. b2-microglobulin urine values indicate renal filtration disorders.
b2-microglobulin is synthesized in the lymphatic system. In Multiple Myeloma, Morbus Hodgkin, cronical lymphatic Leukemia and other malignant Non-Hodgkin Lymphoma elevated b2-microglobulin concentrations are detectable due to elevated cell biosynthesis. In these cases b2-microglobulin levels are a helpful indicator for disease development and therapy estimation. Other diseases with activation of the cellular immune system induce an elevation of b2-microglobulin in serum, too.
In the kidney b2-microglobulin is filtered glomerularly and reabsorbed tubularly. The molecule is not stable in urine with acid pH-values for a long time. A measurement of b2-microglobulin in serum and urine allows a differentiation between an activation of the lymphatic system and a disturbance of the kidney function.   
Indications:
- changing of the glomerular and the tubular filtration        
- lymphatic diseases
- renal tubular damage by heavy metals (Cd, Hg)             
- repulsion of a kidney transplantate
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