產品名稱：25(OH) Vitamin D3 RIA
產    地：Demeditec 
產品貨號：DEKIP1961
產品規格：96 Tests
產品說明：
Special remarks:
Physiological function of 25OH-Vit.D3.
25-Hydroxyvitamin D3 (25OHD3) is the trivial name of 9, 10-secocholesta-5, 7, 10(19)-triene-3b, 25-diol. This secostroid is produced in the liver by 25-hydroxylation of cholecalciferol or Vitamin D3. 25OHD3 is a precursor for other Viamin D metabolites and has only a limited biologiccal activity in itself. The most active derivative is 1a,25-Hydroxyvitamin D3, produced in the kidney (or placenta) by 1a-hydroxylation of 25OHD3. This hormonally regulated steroid stimulates the intestinal absorption of both calcium and phosphorus. It also stimulates bone resorption and mineralization thereby preventing the development of rickets or osteomalacia. This Vitamin D hormone might also be active in other tissues responsible for calcium transport (placenta, kidney, mammary gland,..) and endocrine glands (beta-cells, parathyroid glands, ...), 25-hydroxyvitamin D3 is a main precursor for the metabolites.
Regulatory mechanism
The production of 25-hydroxyvitamin D mainly occurs in the liver although other tissues (intestine, kidney) might perform the same hydroxylation. Although there might be some feed-back inhibition of 25-hydroxyvitamin D on its own production, a higher substrate availability (Vitamin D3) results in higher 25-hydroxyvitamin D production and higher circulating 25-hydroxyvitamin D concentrations in blood. No hormonal or other regulatory mechanism for its synthesis have been clearly identified.
Clinical application for 25OH-Vit.D3 Assay
This assay is of importance for the diagnosis of Vitamin D deficiency or intoxication
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

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