產品名稱：PMN Elastase ELISA
產    地：Demeditec 
產品貨號：DEH3311
產品規格：96 Tests
產品說明：
Special remarks:
The human organism reacts with an inflammatory response to attacks of invading pathogens (micro-organisms  and  viruses)  or  damaged  tissue  (after  accidents  or  surgery).  Polymorphonuclear  (PMN) granulocytes  play  an  important  role  as  primary  defence  cells  in  this  inflammatory  reaction.  Different bloodstream mediators (cytokines, leukotrienes, complement factors, bacterial endotoxins, clotting and fibrinolysis factors) attract and stimulate these cells to phagocytize and destroy not naturally occurring agents.
PMN granulocytes use proteinases to digest these agents and tissue debris. One of these proteinases is PMN elastase which is localised in the azurophilic granules of the polymorphonuclear granulocytes.
During  phagocytosis  of  foreign  substances  these  enzymes  are  also  partially  excreted  into  the extracellular surrounding,  where the activity of PMN  elastase is regulated  by inhibitors (esp. the  α1 -proteinase  inhibitor,  α1 -PI).  An  overwhelming  release  of  PMN  elastase,  however,  can  exceed  the inhibitory  potential  of  the  α1 -proteinase  inhibitor.  Thus,  enzymatically  active  PMN  elastase,  together with simultaneously produced oxidants (O 2 -radicals, H 2 O 2 , OH-radicals), can cause local tissue injury.
Due  to  the  bloodstream  and  lymphatic  system,  however,  α1 -PI  is  delivered  subsequently  and eventually able to form a complex with all excreted elastase. Therefore, the concentration of the PMN elastase/α1 -PI complex correlates with the released PMN elastase and can be used as a measure for the activity of granulocytes during an inflammatory response.
Primarily, determinations of PMN elastase find its application in observation of the course of trauma, shock  and  sepsis.  Further  indications  are  the  areas  of  hemodialysis,  infections  by  obstetrics,  joint diseases,  effusions  of  sport  injuries,  intestinal  affection,  pancreatitis,  cystic  fibrosis  and  male  adnex affections.
上海玉博生物技術有限公司在為生命科學領域提供豐富的產品與信息資源方面處于****地位，公司提供的產品涵蓋了二十多個國家近五十萬種產品，而且產品的數量與信息在不斷的增長和更新，公司提供的產品能夠使生命科學工作者加快對生物化學，分子生物學，細胞生物學以及蛋白質組學研究的認知，以及分子診斷和臨床醫學領域的應用。

產品留言

標題

聯系人

聯系電話

內容

驗證碼

點擊換一張

注：1.可以使用快捷鍵Alt+S或Ctrl+Enter發送信息!
2.如有必要,請您留下您的詳細聯系方式!